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Funding
Current Student PhD Projects
- Molecular modelling and dynamics simulation of proteins and study of the mechanisms of enzyme action
- Cancer and Glutathione S-transferase enzymes - Norman Family Trust
- The role of pyroglutamyl modification of peptides in Alzheimers - Norman Family Trust
- Characteristion of novel enzymes from the marine algal virus EhV-86 and evaluation of their use for commercial biocatalysis - BBSRC CASE PML
- Novel Halogenating and Dehalogenase enzymes from marine microbes - BBSRC CASE Aquapharm
- Intervention of specific protein:protein interactions involved in the management of oxidative stress
- Development of Techniques for the Rapid Monitoring of Biocatalytic Reactions with Applications in Compound Screening, High Throughput Biology and Biotransformation Reactions -
Pfizer
- Structural and Mechanistic Studies on the Transaminase Enzymes
- The application of thermostable esterase and lipase enzymes to medicinal biocatalysis -
Alphamerix, Cambridge/Pro-Bio Faraday
- Acetylation of transcription factors in relation to Oxidative Stress - BBSRC Affiniti/Biomol, Exeter
Current Grants
Previous PhD studentships
- Optimisation of the use of thermophilic alcohol dehydrogenase enzymes for the synthesis of novel chiral alcohols of interest to pharmaceutical industry - BBSRC CASE Chirotech/DowPharma, Cambridge
- Dehalogenase Enzymes - TMO Biotech UK
- Human pyroglutamyl carboxypeptidase and inhibitor development - Chirotech/Dow Cambridge
- Oxidative stress/Arthritis with Dr.C.Jacob and Dr. Jacoby
- Thermophilic Nitrilase Enzymes - Pro-Bio Faraday Industrial Studentship / Stylacats
- Non-Enzymically induced amino acid racemization in human proteins - a possible contributory factor in metabolic dysfunction and complications of diabetes mellitus - With Dr. R. Paisley and Dr. I. Belka ,Torbay Hospital Devon
- Thermostable archaeal esterase enzyme and its application for chiral drug synthesis - BBSRC CASE Chirotech/Dow, Cambridge
- Characterisation of lactamase (amidohydrolase) enzymes of commercial value for chiral drug synthesis - BBSRC CASE Chirotech/Dow, Cambridge
- Thermostable ADH enzymes from the archaea Sulpholobus and Pyrococcus species:applications in chiral drug synthesis - BBSRC CASE Chirotech/Dow, Cambridge
- The bromoperoxidase from marine algae Corallina officinalis - BBSRC CASE Glaxo-Wellcome
Previous Grant Funding
- Structural Studies of Enzymes Important in Biocatalysis and Drug Design - REI Equipment Initiative BBSRC £103,185, 2004-2005
- Glucokinase-Structure and Function Relationships to Normal and Diabetic Forms
Diabetes, UK £10,000, 2002-2003
- Development of Novel Thermostable Biocatalysts
BBSRC Japan Partnership Award £20,000, 2002-2005
- The Exploitation of Vanadium Haloperoxidase Enzymes in Applied Biocatalysis
BBSRC £209,076, 2002-2005
- Structural Studies on two Gamma Lactamase Enzymes with Opposite Stereospecificity
BBSRC £222,340, 2001-2004
- Structure and Function of Normal and Diabetic forms of human glucokinase
British Diabetic Association £61,542, 1999-2002
- A mass spectrometer for synthetic and biological chemistry.
EPSRC/BBSRC joint committee. £114,143, 1999
Application with Prof. C. Moody and Prof. D. Bruce
- Enhancement of X-Ray Facilities at Exeter.
BBSRC £117,500, 1999
- European Commission Grant Framework Four.
Biotransformations using baeyer-villiger mono-oxygenases.
With groups in Netherlands, Italy, France and two industrial companies, Fluka and GSM.
Euro 253,000 (for Exeter), 1998-2000
- Structural Characterisation of a novel human antioxidant protein. BBSRC £181,484, 1998-2001
- X-Ray Structural Studies of the Vanadium Bromoperoxidase from the Marine Algae Corallina officinalis.
BBSRC £152,980, 1998-2001
- Thermostable Enzymes as Catalysts for the Production of Single Enantiomeric Compounds
BBSRC Biocatalysis Programme with DTI/Chiroscience. £330,000, 1998-2001
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