Programme

Preliminary Programme

Wednesday 11th April 2007

10.30 onwards	Registration and Coffee
11.30 - 12.00	Opening of Meeting	Welcome to the University of Exeter, Deputy VC Welcome from Professor Littlechild
12.00 - 1.00	Plenary Lecture Professor Robert Huber Max-Planck Institute for Biochemie, Martinsried, Germany	The proteasome and related protease assemblies
1.00 - 2.00	Buffet Lunch
2.00 - 2.45	Professor Roy Daniel Department of Biological Sciences, University of Waikato, New Zealand	The effect of temperature on enzymes: new insights and their implications
2.45 - 3.30	Professor Alan Cooper Department of Chemistry, University of Glasgow, UK	Pressure peturbation calorimetry, heat capacity, and the role of water in protein stability and interactions
3.30 - 4.00	Tea & putting up of posters
4.00 - 4.45	Professor Jon Waltho Krebs Institute, University of Sheffield, UK	NMR Investigation of structural tightening in proteins
4.45 - 5.30	Professor Mike Danson Centre for Extremophile Research, Dept. of Biology and Biochemistry, University of Bath, UK	Enzyme catalysis near 100C: the structural basis of enzyme promiscuity and activity in the hyperthermophilic Archaea
5.30 - 5.50	Dr Ruhong Zhou IBM Watson Research Center, New York, USA	Destruction of long-range interactions and stability by a single mutation in lysozyme
5.50 - 6.10	Professor Akihiko Yamagishi Tokyo University of Pharmacy & Life Science, Tokyo, Japan	Evolutional aspects of protein stability
6.30	Welcome Reception

Thursday 12th April 2007

	Protein Stabilisation
9.00 - 9.15	Chair: Professor Mike Danson	Introductory remarks
9.15 - 9.50	Professor Jenny Littlechild Henry Wellcome Building for Biocatalysis, University of Exeter, UK	Natural methods of protein stabilisation - Thermostable biocatalysts
9.50 - 10.25	Dr David Brockwell Institute of Molecular and Cellular Biology, University of Leeds, UK	Probing the mechanical stability of proteins using the Atomic Force Microscope
10.25 - 10.45	Dr Michael Gromiha Computational Biology Research Centre, AISY, Tokyo, Japan	Prediction of protein stability upon single mutations
10.45 - 11.30	Coffee and Poster Session I
11.30 - 12.05	Professor Milan Polakovic Slovak University of Technology, Slovakia	Kinetic methods in the investigation of mechanism of enzyme inactivation
12.05 - 12.30	Dr Rob Brown Diversa Corp., USA	Solubilisation, stabilisation & assembly of a highly conserved enteric bacterial outer surface protein (OspA) fusion induces protection against organ invasion by Salmonella enterica serovar Enteritidis in young chickens
12.30 - 1.30	Lunch
1.30 - 2.05	Dr Mike Taussig The Babraham Institute, Cambridge, UK	Protein arrays and protein display systems
2.05 - 2.30	Dr Gregory Poon Ontario Cancer Institute, Toronto, Canada	Stabilization of an oligomerization domain by tandem dimerization. Application to human p53 tet domain: thermodynamics and biological implications
2.30 - 2.55	Dr Paul Docherty Novexin Ltd, UK	Improving the stability of proteins through the use of carbohydrate polymers
2.55 - 3.20	Professor Eduardo P. Melo Centre for Molecular and Structural Biomedicine, University of Algarve, Portugal	Insight into stability of multi-copper oxidases
3.20 - 3.35	Dr Daniel Rochu Centre de Recherches du Service de Santoe des Armees, France	Stabilisation of the active form(s) of human paraoxonase by human phosphate binding protein
3.35 - 3.50	Dr Izabela Zakowska National Chiao Tung University, Taiwan	Protein folding and aggregation: competitive reactions
3.50 - 4.10	Tea
	Enzyme Immobilisation
4.10 - 4.25	Chair: Professor Antonio Ballesteros	Introductory remarks
4.25 - 5.00	Professor Peter Halling University of Strathclyde, UK	Biocatalyst post-mortems: analysing causes of immobilised enzyme inactivation using spectroscopic and proteomic methods
5.00 - 5.35	Professor Roger Sheldon Delft University of Technology, Netherlands	Cross-Linked Enzyme Aggregates : Stable and recyclable biocatalysts
5.35 - 6.30	Wine Reception and Poster Session
7.30	Gala Dinner

Friday 13th April 2007

	Protein Stabilisation II
9.00 - 9.15	Chair: Professor Stanislaw Bielecki	Introductory Remarks
9.15 - 9.45	Professor Kurt D Berndt Centre for Biosciences, Karolinska Institutet, Sweden	Quantifying specificity: Using chemical proteomics and ligand-induced stability to probe the active site of E. coli glutaredoxin-3
9.45 - 10.15	Dr Barry Moore Pure and Applied Chemistry, University of Strathclyde & XstalBio Ltd, UK	An inside-out approach to protein stabilisation
10.15 - 10.45	Dr Guido Drago Applied Enzyme Technology Ltd, Gwent, UK	The stability of screen printable enzyme biosensor inks
10.45 - 11.15	Coffee and Poster Session II
11.15 - 11.45	Professor Bernd Nidetzky Institute of Biotechnology & Biochemical Engineering, Graz, Austria	Dissecting the stabilising effects of immobilisation in D-amino acid oxidase
11.45 - 12.15	Dr Roberto Fernandez-Lafuente Institute of Catalysis, CSIC, Madrid, Spain	Dramatic stabilisation of mutated penicillin G acylase via site-directed multipoint covalent immobilisation: chemical and geometric congruence between enzyme and support surfaces
12.15 - 12.30	Dr Anne-Marie Hickey University of Exeter, UK	Immobilisation of thermophilic enzymes in miniaturised flow reactors
12.30 - 1.30	Lunch
	Biocatalysis
1.30 - 1.45	Chair: Dr Roland Wohlgemuth	Introductory remarks
1.45 - 2.20	Dr Jan-Metske van der Laan DSM, Delft, The Netherlands	Improving biocatalyst performance by directed evolution
2.20 - 2.55	Dr Hazel Housden CNAP, Dept. Biology, University of York, UK	Biocatalysis and protein interactions in ionic liquids
2.55 - 3.30	Professor Andreas Bommarius Georgia Institute of Technology, USA	Predicting biocatalyst stability in aqueous salt solutions
3.30 - 4.05	Dr Paul Dalby Biochemical Engineering, UCL, London, UK	Stability of enzyme biocatalysts
4.05 - 4.25	Ms Erika Feher University of Pannonia, Hungary	Continuos enzymatic production of isoamyl acetate in ionic liquid - alcoholic biphasic system
4.25 - 4.40	Tea
4.40 - 5.10	Dr Nevin Gül-Karagüler Istanbul Technical University, Turkey	Protein engineering applications on industrially important enzymes: Bacillus stearothermophilus LDH and Candida methylica FDA
5.10 - 5.30	Mr Volker Höllrigl University of Dortmund, Germany	Thermophilic alcohol dehydgrogenase from Thermus sp. for electroenzymatic applications
5.30	Close of Meeting

Saturday 14th April 2007
Organised Tours - details to be confirmed