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In patients with diabetes, tight control of blood glucose is proven to reduce the risk of developing complications. This is, however, difficult to achieve in practice due to the associated increased risk of hypoglycaemia. Some studies using fMRI have implicated the hypothalamus as the centre responsible for regulation of plasma glucose concentration, energy intake and feeding behaviour. Thus, the aim of the present study was to assess whether it is possible to measure activation within the hypothalamus following glucose ingestion and to determine the time course of this activation.
Benattayallah A, Flanagan D, Krishnan B, Ball C, Fulford J, Macleod K, Summers I.R, Shore A. Functional Magnetic Resonance Imaging (fMRI)-A Useful Tool for the Assessment of Hypothalamus Function?. In Proceedings of the 15th Annual Scientific Meeting of the ISMRM, Berlin, Germany, May 2007.